3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Names and Identifiers

Name	SR9009
Synonyms	SR9009 CS-2027 STENABOLIC Stenabolic (SR9009) SR9009 sarms,whnohe_lucy(at)163.com SR9009 Powder whnohe_carolineat163.com Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate 3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester
CAS	1379686-30-2
EINECS	1592732-453-0

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Physico-chemical Properties

Molecular Formula	C20H24ClN3O4S
Molar Mass	437.94
Density	1.327±0.06 g/cm3(Predicted)
Boling Point	547.2±45.0 °C(Predicted)
Physical and Chemical Properties	Acidity coefficient (pKa) 6.12±0.50(Predicted)

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Upstream Downstream Industry

Raw Materials

1-Pyrrolidinecarboxylic acid, 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-, 1,1-dimethylethyl ester
N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine
5-NITROTHIOPHENE-2-CARBOXALDEHYDE
Ethyl chloroformate
4-Chlorobenzylamine

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Introduction

biological activity

Stenabolic (SR9009) is a synthetic REV-ERB agonist. The IC50 values for REV-ERB-α and REV-ERB-β are 670 nM and 800 nM, respectively.

target

Target Value

REV-ERB-α

(HEK293 cells) 670 nM

REV-ERB-β

(HEK293 cells) 800 nM

in vitro study

SR9009 has a lethal effect on cancer cells and aging cells induced by oncogenes (including melanocytic nevus), but has no effect on the vitality of normal cells and tissues. SR9009 regulates autophagy and lipid neogenesis, which plays a key role in inducing apoptosis in malignant cells. The treatment of cancer cells was treated with SR9009. By detecting caspase3 splicing and TUNEL test, the treatment of SR9009 cancer cells reduced their cell viability because apoptosis was induced. SR9009 reduces the number of autophagosomes, thus inhibiting autophagy.

in vivo studies

In food-borne obese mice, SR9909 can cause a decrease in fat mass and blood lipids. In vivo, SR9009 can inhibit the growth of malignant glioma and improve its survival rate in mice without causing obvious toxicity. SR9009 can penetrate the blood-brain barrier and inhibit tumor growth in a transplanted tumor model using malignant glioma migration from patients. In two different malignant glioma models, the survival rate is significantly improved.

Last Update：2024-04-09 20:52:54

Shanghai Worldyang Chemical Co.,Ltd.

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester

SR9009

CAS: 1379686-30-2

Molecular Formula: C20H24ClN3O4S

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Names and Identifiers

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Physico-chemical Properties

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Upstream Downstream Industry

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Introduction

Supplier List

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester Request for Quotation

SR9009

CAS: 1379686-30-2

Molecular Formula: C20H24ClN3O4S

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Names and Identifiers

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Physico-chemical Properties

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Upstream Downstream Industry

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester - Introduction

Supplier List

3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester